Hormone Balancing Naturally


“With certified non-GMO soy isoflavones, clover leaf extract, and chaste tree berry, Progest Liposome Cream is a great natural alternative for natural hormone balance.”


Hormonal balance

Life is a balancing act, especially for women. Hormone balance is essential to nearly all functions in the body including growth and development, sex and reproduction, mood, sleep, or the way the body utilizes food. When your hormones are in balance, you feel great, look great, have sustainable energy, a healthy appetite and a healthy sex drive.

Many diseases or illnesses are thought to be related to excess estrogen and a deficiency in progesterone. Some women’s bodies do not make enough progesterone, leading to what is called unopposed estrogen. Unopposed estrogen is called estrogen dominance in some medical literature. Without progesterone’s balancing influence, estrogen can work overtime in your body and cause cell overgrowths, like tumors in your uterine lining, and weight gain influenced by insulin resistance, fibrocystic breast disease, certain types of PMS, migraines, menstrual disturbances—irregular and heavy bleeding, endometriosis, the uterine tissue disorder.

When all things are normal, estrogen and progesterone work in harmony to prevent the lining of your uterus from getting too thick. As we age, or due to excess environmental toxins or stress, estrogen levels drop by only 40-60% at menopause—which is just enough to stop the menstrual cycle—but progesterone levels may drop to near zero in some women. It is this imbalance of estrogen to progesterone that causes sickness. Progesterone is a precursor to many steroid hormones; its use can greatly enhance overall hormone balance after menopause. Progesterone also stimulates bone-building and thus helps protect against osteoporosis.

What works and what does not for menopause symptoms?

Of course, there are many over the counter products on the market promising the reduction of menopausal symptoms e.g. supplements or creams containing wild yam while, in fact, they do not work. It should be pointed out that wild yam does not convert to progesterone within the body, wild yam the plant has no proven hormonal action, nor have any studies shown it to be effective in treating hormone related disorders. It is true that diosgenin can be converted into steroidal compounds, which are then used in the chemical synthesis of progesterone, but this happens in a laboratory—not in the human body. There is essentially no scientific evidence of wild yam’s effectiveness in treating either menopausal symptoms or osteoporosis. Moreover, many products that claim to contain natural progesterone actually contain synthetic medroxyprogesterone acetate (MPA).

Soy, on the other hand, which has been a dietary staple in Asian countries for centuries, has been proven to have positive effects. And, perhaps it is no coincidence that rates of heart disease, cancer and other serious diseases happen to be much lower among Asian cultures. Soy undoubtedly has a good deal of nutritional value. This member of the legume family contains abundant amounts of protein, fiber, lecithin and B vitamins. Soy is also a rich source of various isoflavones, a class of phytoestrogens—plant-derived compounds with estrogen-like activity that mimic this hormone in the body. In addition to reducing symptoms such as hot flashes, soy contains powerful anticancer phytochemicals. Genistein and daidzein, the two most important soy isoflavones, are converted in the body to phytoestrogens, balancing high estrogen levels. These phytoestrogens can also block estrogen receptors in certain hormone-dependent tissues such as the breast and uterus, helping to protect against cancer. The one main issue with soy is that most of the soy in the world is genetically modified, whereas certified non-GMO soy deserves special attention because of its well-researched[1] properties. If you are sensitive to soy products, isolated soy isoflavone supplements or cream are often tolerated.

Doctor’s Choice Progest Liposome Cream

After years on research and development, Doctor’s Choice has created a unique topical cream formulated with USP pharmaceutical grade ingredients, and supported by scientific evidence[2] to help boost endogenous progesterone, and balance the body hormones.

Doctor’s Choice Progest Liposome Cream is an excellent option to help balance female hormones during the different phases and cycles of life, from menstruation to menopause. Formulated by a naturopathic doctor, it was designed to work like progesterone as much as legally possible, since progesterone is a drug. Supplementing with natural Progest Liposome Cream simulates the body’s own hormone production and helps to bring balance and equilibrium back to the body by decreasing the symptoms.[3]

Isoflavones in topical cream and how the cream works

We use certified non-GMO soy isoflavones, which is known to stimulate fibroblast to make collagen and hyaluronic acid, and thought to prevent the skin from physiological aging, with the ability to prevent UV damage. Studies have demonstrated an interrelation between photo-aging, the decline of estrogen in women, and reduced skin elasticity.

Progest Liposome Cream uses an almost flawless liposome[4] delivery. When phospholipids combine with water, they immediately form a microscopic sphere because one end of the phospholipid structure is very water loving. The opposite end is fatty in nature and thus is water insoluble. Water soluble substances can be trapped inside the water sphere while fat soluble substances can be trapped inside the fat-soluble opposite end of the molecule. Absorption becomes almost perfect which solves many problems for special nutrient deficiencies of substances which are poorly absorbed or which have a normal molecular size that would inhibit efficient absorption.

Progest Liposome Cream uses bio-active ingredients like clover, rosemary, grapefruit and pomegranate. These ingredients show anti-estrogenic properties to help the secretion of endogenous progesterone that can be beneficial to restore progesterone and estrogen function.

Progest Liposome Cream’s therapeutic effects are enhanced when combined with Thyrodine® Thyroid Gland or Thyromoto® Thyroid Gland in case of an auto-immune deficiency since thyroid deficiency causes hormonal imbalance.

Directions of use: Premenstrual[5]

Day 1-14: do not use the cream; day 15-18: use 1/8 tsp. twice per day; day 19-23: use 1/4 tsp. twice per day; day 24 to the day period starts: use 1/2 tsp. twice per day. Adjust this schedule to meet your individual needs by gradually cutting back on the amount of cream used each month as improvements warrant.

Directions of use: Menopause

Day 1-7: do not use cream; day 8-21: use 1/4 tsp. twice per day; day 22-1st day of the next menstruation: use 1/2 tsp. twice per day. If you are no longer menstruating, follow the suggested schedule below, based on the calendar month.

Some women find that they must use 1/2 tsp. twice per day, every day, to get relief from menopausal symptoms. If skipping the application in the first seven days leaves you with uncomfortable symptoms, you may use this cream every day of the month.  If symptoms have not receded after several weeks of use, then a small amount of the cream for a limited time may be appropriate.



In America:

  • The American Institute of Cancer Research found that women who have had breast cancer can safely consume soy foods, non-GMO.
  • For breast cancer survivors who want a more plant-based diet, with less meat and more protein, soy is a safe and healthy alternative.

In Canada:

  • Researchers undertook a two-year clinical trial evaluating the health effects of soy isoflavones, both alone and combined with exercise.
  • Over 300 postmenopausal women were studied.
  • Soy was found to be effective for improving leg strength and soy either alone or with exercise also lowered LDL-cholesterol by 6%.
  • Soy also reduced adverse menopausal symptoms, such as breast tenderness, decreased concentration, depression, fatigue, hot flashes, insomnia, numbness, vaginal dryness and itching, night sweats, subjective weight gain, migraines, anxiety, irritability, and changes in bleeding patterns.
  • Also, soy isoflavone cream supplementation did not affect two measures of safety, endometrial thickness and mammographic density, which are both assessed to determine the risk of endometrial and breast cancer, respectively. These results agree with a large dataset showing isoflavones do not affect these markers.


References and further readings:

  • Colacurci, Nicola et al. 2013. Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29,3: 209-12. doi:10.3109/09513590.2012.738724
  • Fritz, Heidi et al. 2013. Soy, red clover, and isoflavones and breast cancer: a systematic review. PloS one 8,11 e81968. 28 Nov. doi:10.1371/journal.pone.0081968
  • Khrouf, Mohamed et al. 2017. Progesterone for Luteal Phase Support in In Vitro Fertilization: Comparison of Vaginal and Rectal Pessaries to Vaginal Capsules: A Randomized Controlled Study. Clinical medicine insights. Women’s health 9 43-47. 5 Jan. doi:10.4137/CMWH.S32156
  • Silverstein, Marnie G et al. 2014. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause (New York, N.Y.) 21,10: 1136-42. doi:10.1097/GME.0000000000000223

[1] Studies regarding the benefits of soy: Colacurci, Nicola et al. 2013. or Fritz, Heidi et al. 2013.

[2] Silverstein, Marnie G et al. 2014.

[3] To learn more about the positive effects of progesterone:  Khrouf, Mohamed et al. 2017.

[4] A liposome is a microscopic, fluid-filled pouch whose walls are made of layers of phospholipids identical in makeup to the phospholipids that make up cell membranes. It can deliver substances to the blood stream more efficiently than normal.

[5] For more instructions visit https://doctorschoice.ca/product/progest-liposome-cream-59g/.